All eyes are on this season’s new developments in ILD management and diagnosis.
Supported by an educational grant from Boehringer Ingelheim Pharmaceuticals, Inc.

The IPF Cell Atlas
Launched: November 22, 2019

Senescence, Senolytics, and IPF
Launched: November 13, 2019

 
 

The PRECISIONS Study
Launched: November 13, 2019

Genomics and Transcriptomics in PF
Launched: November 13, 2019

 
 

Recent Findings from PF Registries
Launched: November 13, 2019

Recent Developments in IPF Diagnosis
Launched: November 13, 2019

 
 

Evaluating Pulmonary Rehab Added on to Antifibrotic Therapy
Launched: November 13, 2019

New Developments in Clinical Trials of Pulmonary Fibrosis
Launched: November 13, 2019

 

 
 

Antifibrotic Therapy in Patients w/Autoimmune-Associated ILD
Launched: November 13, 2019

Evaluating Gene Expression of Alveolar Macrophages and SAECs
Launched: November 13, 2019

 

 
 


Expanding the Use of Antifibrotic Therapy in Patients with PF

Launched: November 22, 2019

Considerations for the Management of Autoimmune-Related ILD and Chronic Hypersensitivity-Related ILD
Launched: November 22, 2019

 

 
 

Key Takeaways from Recent Pulmonary Conferences
Launched: November 13, 2019

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Listen to experts report on current publications, posters, and sessions from a recent rheumatology conference. Faculty discuss the latest on Systemic sclerosis ILD and Progressive fibrosing ILD and discuss the implication of this information on current clinical practices for clinicians.
Supported by an educational grant from Boehringer Ingelheim Pharmaceuticals, Inc.

Updates on Current Treatment Options for RA-ILD
Launched: June 12, 2020

New Treatment Options for SSc-ILD
Launched: June 12, 2020
 

 

 
 

Therapies on the Horizon for RA-ILD
Launched: June 12, 2020

New Directions in the Diagnosis of RA-ILD
Launched: June 12, 2020

 

 
 

Monitoring for Changes in Disease Course and Comorbidities in SSc-ILD
Launched: June 12, 2020

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Here are some important highlights from the meeting.
Supported by educational grants from Boehringer Ingelheim Pharmaceuticals, Inc., and Actelion.

 

Transbronchial Cryobiopsy for the Diagnosis of ILD
— Dr. Paul W. Noble

Fleischner Society Update in Classification of IPF
— Dr. David A. Lynch

 


ICD-10 Codes and Nomenclature for Classification of PAH
— Dr. Ronald J. Oudiz

NTM and Treatment Strategies for Patients with Cavitary Disease
— Dr. Sandra G. Adams

 


Real World Experience in Patients with COPD
— Dr. Sandra G. Adams

Palliative Care for Patients with IPF
— Dr. Meena Kalluri

 

 


New Developments in the Diagnosis and Management of IPF
— Dr. Anoop M. Nambiar

Registry Data Provide Important Severity Indicators for PH
— Dr. Ronald J. Oudiz

 


The Latest in IPF: Implications for Clinical Practice
— Drs. Lisa H. Lancaster &  Maria L. Padilla

Perspectives on Side Effect Management
— Drs. Lisa H. Lancaster &  Maria L. Padilla

 


IPF Management Considerations
— Drs. Lisa H. Lancaster &  Maria L. Padilla

Questions for the experts | Transcript

 

 

 

 

 


Conference Coverage Q&A

 
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Dr. Lynch discussed the new Fleischner Society diagnostic criteria for IPF. What are the new diagnostic categories of usual interstitial pneumonia (UIP), based on CT patterns?

Ask the Expert  

The following table includes the distribution and features associated with the 4 different diagnostic categories of UIP based on CT patterns from the new Fleischner Society guidelines.

Lynch DA, et al. Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper. Lancet Respir Med. 2018;6:138-153. https://www.ncbi.nlm.nih.gov/pubmed/29154106




Dr. Nambiar said that combination studies with pirfenidone and nintedanib have shown that treatment with the antifibrotic agents combined is well tolerated. What were the most common adverse events, and is there any information yet on the efficacy of combination treatment?

Ask the Expert  

Vancheri et al have recently published results from an open-label trial of nintedanib with add-on pirfenidone in patients with IPF (the INJOURNEY Trial). In this study, patients with IPF and FVC ≥50% predicted at screening who completed a 4–5 week run-in with nintedanib 150 mg bid without dose reduction or treatment interruption were randomized to nintedanib 150 mg bid with add-on pirfenidone (titrated to 801 mg tid) (n = 53), or nintedanib 150 mg bid alone (n = 52), open-label for 12 weeks. The primary endpoint was the percentage of patients with on-treatment gastrointestinal adverse events from baseline to week 12. Analyses were descriptive and exploratory. GI AEs were reported for 69.8% of patients treated with nintedanib with add-on pirfenidone and in 52.9% of patients treated with nintedanib alone. Diarrhea, nausea and vomiting were the most frequent AEs, occurring in 37.7%, 41.5% and 28.3% respectively, with combination treatment, compared with 31.4%, 11.8%, and 11.8% with nintedanib treatment alone. At 12 weeks, the mean absolute change from baseline in FVC was -13.3±17.4 mL in the nintedanib + pirfenidone group compared with -40.9 ± 31.4 mL for nintedanib treatment alone.

Vancheri C, et al. Am J Respir Crit Care Med. 2017 Sep 10. [Epub ahead of print] Nintedanib with Add-on Pirfenidone in Idiopathic Pulmonary Fibrosis: Results of the INJOURNEY Trial. Available at https://www.ncbi.nlm.nih.gov/pubmed/28889759. Accessed November 30, 2017.

An open-label, single arm, 24 week safety and tolerability study of pirfenidone in combination with nintedanib has also been conducted in patients with IPF (NCT02598193), however the results of this study have not been published to date.




Independent Conference Coverage from the CHEST 2019 Annual Meeting*
Supported by an educational grant from Boehringer Ingelheim Pharmaceuticals, Inc.


Current Perspective on Antifibrotic Therapy for Patients with IPF

Launched: October 25, 2019

Nintedanib in Progressive Fibrosing Interstitial Lung Diseases (The INBUILD Trial)
Launched: October 25, 2019


Goals of Care Across the Disease Continuum in IPF
Launched: October 25, 2019

Emerging Diagnostic Approaches to Patients with ILD
Launched: October 25, 2019


Pirfenidone in Patients with Unclassifiable Interstitial Lung Disease
Launched: October 25, 2019


Considerations for Geriatric ILD Patients

Launched: October 25, 2019



Nintedanib for Patients with Systemic Sclerosis-Related Interstitial Lung Disease

Launched: October 25, 2019

Inhaled NO in Patients at Risk for Pulmonary Hypertension Associated with Pulmonary Fibrosis
Launched: October 25, 2019


Clinical Pearls from New Orleans 2019
Launched: October 24, 2019

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*This coverage is not sanctioned by the conference organizers and is not an official part of the conference proceedings of the 2019 CHEST Annual Meeting.

 


Here are some important highlights from the meeting.
Supported by an educational grant from Boehringer Ingelheim Pharmaceuticals, Inc.
 

 

New Research on Mechanisms in the Development of PF
— Dr. Sonye K. Danoff

Exploring New Therapeutic Avenues for Managing PF
— Dr. Sonye K. Danoff

 


New Approaches to the Diagnosis of IPF
— Dr. Timothy P. Whelan

Updates on Registry Enrollment and Growth of the Care Center Network
— Dr. Timothy P. Whelan

 


Exploring the Basic Mechanisms that Contribute to Development of Lung Fibrosis
— Drs. Danoff and Whelan

Transcript

Gene Abnormalities and ILD
— Drs. Danoff and Whelan
 

Transcript

 


Environmental Influences on the Development of Pulmonary Fibrosis
— Drs. Danoff and Whelan

Genetics and Personalized Medicine for Patients with Pulmonary Fibrosis
— Drs. Danoff and Whelan