Pulmonary Lymphangitic Carcinomatosis
Pulmonary Lymphangitic Carcinomatosis

Adenocarcinoma is the most common tumor to present in this way. Lymphangitic carcinoma may represent as much as 8% of all metastatic disease in the lung. The most common sites of primary tumor are 1) lung (with intrapulmonary spread), 2) breast, and 3) stomach. Less commonly metastases from primary tumors in ovary, pancreas, kidney, and uterine cervix can present in this way. This image shows the characteristic distribution of lymphangitic carcinoma in the lung. Tumor fills lymphatic channels as they naturally course along bronchovascular bundles, interlobular connective tissue septa, and in pleura. Hematoxylin and eosin stain; 12x original magnification. Click to next image for higher magnification.